Open AccessCytopathic effects of toxogenic strains of Helicobacter pylori on different cell lines
Author(s) -
K. Lakshmana Gowda,
Mohammed Ali M. Marie,
James John,
C. S. Pradeep,
Khaled Homoud M. Dabwan,
Godhandaraman Sangeetha
Publication year - 2014
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.134660
Subject(s) - caga , vero cell , virulence , toxin , microbiology and biotechnology , helicobacter pylori , biology , virulence factor , cell culture , titer , virology , gene , virus , biochemistry , genetics
Many virulence factors are involved in the pathomechanism of infection caused by Helicobacter pylori. Toxins such as vacuolating cytotoxin, encoded by the vacA gene and the immunogenic protein cagA, encoded by the cagA gene (cytotoxin-associated gene) are major factors conferring the property of virulence. The current study is aimed at isolation of H. pylori and separation of its toxin from antral biopsies of patients.