Open AccessAbsence of anaplastic lymphoma kinase-1 expression in inflammatory myofibroblastic tumors of the central nervous system: Does it signify a different nosologic entity from its systemic counterpart?
Author(s) -
Aparna Govindan,
Anita Mahadevan,
Shrijeet Chakraborti,
Sunil V. Furtado,
Susarla Krishna
Publication year - 2014
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.134658
Subject(s) - anaplastic lymphoma kinase , pathology , immunohistochemistry , cd68 , lymphoma , medicine , anaplastic large cell lymphoma , vimentin , immunophenotyping , b cell lymphoma , antigen , immunology , malignant pleural effusion , lung cancer
Inflammatory myofibroblastic tumors (IMFTs) are uncommon neoplasms of the central nervous system (CNS) of intermediate grade biologic potential. Anaplastic lymphoma kinase (ALK-1), a diagnostic marker of anaplastic large cell lymphoma, is also expressed in a subset of IMFTs and appears to have prognostic significance. Though, few studies have evaluated expression of ALK-1 in IMFTs of the CNS. This retrospective study was undertaken to evaluate the expression of ALK-1 expression in IMFT of CNS by immunohistochemistry and correlate with the clinical, radiological and pathologic features.