Open AccessPelvic mature cystic teratoma with neuroendocrine carcinoma: Report of a rare association and review of literature
Author(s) -
Mukund Sable,
Debojit Nath,
Sunil Chumbar,
Chandan Jyoti Das,
Pratyusha Priyadarshini,
Kavneet Kaur,
Richa Ranjan,
Siddhartha Datta Gupta,
Prasenjit Das
Publication year - 2014
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.130916
Subject(s) - malignancy , malignant transformation , germ cell tumors , teratoma , histopathological examination , pathology , germ cell , medicine , mature cystic teratoma , biology , biochemistry , chemotherapy , gene
Extra-gonadal malignant transformation of teratoma is rare and there are only a few reports available citing malignancy arising in the non-germ cell components. We hereby report a case of a 35-year-old female, who presented with lower backache with a radiologically identifiable mass lesion in the pre-sacral region. Clinical and radiological findings suggested the possibility of a cystic teratoma. Histopathological examination and relevant immunohistochemical tests detected a mature cystic teratoma with features of a grade 2 neuroendocrine tumor in it. Like the index case, most of the previously reported cases of teratoma with malignant transformation of the somatic components were found in extra-gonadal site. This case is being reported to emphasize that any extra-gonadal mass in reproductive age group, even if it appears radiologically and per-operatively benign, must be subjected to histopathological examination to rule out possibility of malignant transformation of the germ cell or non-germ cell components.