Open AccessThe correlation between p16 expression and INK4a locus mutation with grades and stages in oral squamous cell carcinoma
Author(s) -
Soudabeh Sargolzaei,
Sareh Farhadi,
Bahram Kazemi,
Mojgan Bandehpour,
Mohammad Javad Kharazifard
Publication year - 2014
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.130877
Subject(s) - locus (genetics) , basal cell , correlation , microbiology and biotechnology , epidermoid carcinoma , gene , polymerase chain reaction , lymph node , carcinoma , tumor suppressor gene , biology , cancer research , medicine , pathology , genetics , carcinogenesis , geometry , mathematics
p16INK4a is a tumor suppressor gene playing a critical role. Researches have indicated the gene to be altered in oral squamous cell carcinoma. Present studies have tried to assess the correlation between p16INK4a expression and INK4a locus mutation in relation to grades and stages of this tumor.