Open AccessT-lineage acute lymphoblastic leukemia and parvovirus infection in a child with neurofibromastosis-1
Author(s) -
Pallavi Agarwal,
Shano Naseem,
Neelam Varma,
R. K. Marwaha
Publication year - 2013
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.125366
Subject(s) - pancytopenia , parvovirus , medicine , neurofibromatosis , lymphoblastic leukemia , lineage (genetic) , acute lymphocytic leukemia , leukemia , chemotherapy , immunology , pathology , bone marrow , biology , virus , gene , biochemistry
Neurofibromatosis (NF-1) patients have an increased risk of developing malignancies most commonly rhabdomyosarcomas, optic gliomas, brain tumors and non-lymphocytic leukemias. Acute lymphoblastic leukemia (ALL) has been infrequently reported in association with NF-1. We describe a rare association of NF-1, T-lineage ALL and parvovirus infection in a 12-year-old child. In addition, it is also to emphasize that a high index of suspicion should be kept for parvovirus B19 infection as a cause of bicytopenia/pancytopenia in ALL patients following induction chemotherapy.