Open AccessInhibiting valosin-containing protein suppresses osteosarcoma cell metastasis via AKT/nuclear factor of kappa B signaling pathway in vitro
Author(s) -
Xin Long,
Zhi Hong Zhang,
Zhi Li Liu,
Shan Huang,
Qing Luo
Publication year - 2013
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.120358
Subject(s) - protein kinase b , cancer research , gene silencing , metastasis , western blot , phosphorylation , kinase , microbiology and biotechnology , chemistry , medicine , biology , cancer , biochemistry , gene
The strategies of targeting valosin-containing protein (VCP) may have therapeutic potential for treating cancer metastasis. In this study, we aim to investigate the correlation of VCP protein expression in osteosarcoma (OS) tissues with pulmonary metastasis and its possible molecular mechanism.