Open AccessImportance of P53, Ki-67 expression in the differential diagnosis of benign/malignant phyllodes tumors of the breast
Author(s) -
Ülkü Küçük,
Ümit Bayol,
Emel Ebru Pala,
Süheyla Cumurcu
Publication year - 2013
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.118690
Subject(s) - phyllodes tumor , stromal cell , staining , pathology , immunohistochemistry , ki 67 , hormone receptor , grading (engineering) , medicine , progesterone receptor , estrogen receptor , breast cancer , biology , cancer , ecology
Conventionally growth pattern, stromal overgrowth, stromal cellularity and stromal mitotic activity are the main parameters in the grading of phyllodes tumors (PTs). Recent studies revealed that both p53 and Ki-67 expressions are correlated with grade of PTs of the breast. Expression of hormone receptors and overexpression/amplification of HER2 has been studied in PTs to discover the roles of these markers as new treatment modalities.