Open AccessNodal mantle cell lymphoma: A descriptive study from a tertiary care center in South India
Author(s) -
Arun Grace Roy,
Rakhee Kar,
Debdatta Basu
Publication year - 2013
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.118680
Subject(s) - cd5 , pathology , immunophenotyping , mantle cell lymphoma , lymphoma , medicine , lymph node , cyclin d1 , cytopenia , biopsy , population , bone marrow , cancer , immunology , flow cytometry , environmental health , cell cycle
Mantle cell lymphoma (MCL) is a type of B-cell non-Hodgkin lymphoma (NHL) with distinctive morphologic, immunophenotypic and a characteristic cytogenetic abnormality, the t(11;14)(q13;q32) and overexpression of cyclin D1. The common histologic features include effaced lymphoid architecture by a monomorphic lymphoid population with a vaguely nodular, diffuse or mantle zone growth pattern. The classic cytomorphologic features include small to medium sized lymphoid cells with irregular nuclear contours and scanty cytoplasm, closely resembling centrocytes.