Nodal mantle cell lymphoma: A descriptive study from a tertiary care center in South India | Zendy

Arun Grace Roy | Zendy; Rakhee Kar | Zendy; Debdatta Basu | Zendy

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Nodal mantle cell lymphoma: A descriptive study from a tertiary care center in South India

Author(s) -

Arun Grace Roy,

Rakhee Kar,

Debdatta Basu

Publication year - 2013

Publication title -

indian journal of pathology and microbiology

Language(s) - English

Resource type - Journals

eISSN - 0974-5130

pISSN - 0377-4929

DOI - 10.4103/0377-4929.118680

Subject(s) - cd5 , pathology , immunophenotyping , mantle cell lymphoma , lymphoma , medicine , lymph node , cyclin d1 , cytopenia , biopsy , population , bone marrow , cancer , immunology , flow cytometry , environmental health , cell cycle

Mantle cell lymphoma (MCL) is a type of B-cell non-Hodgkin lymphoma (NHL) with distinctive morphologic, immunophenotypic and a characteristic cytogenetic abnormality, the t(11;14)(q13;q32) and overexpression of cyclin D1. The common histologic features include effaced lymphoid architecture by a monomorphic lymphoid population with a vaguely nodular, diffuse or mantle zone growth pattern. The classic cytomorphologic features include small to medium sized lymphoid cells with irregular nuclear contours and scanty cytoplasm, closely resembling centrocytes.

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