Open AccessAlfa-fetoprotein secreting ovarian sex cord-stromal tumor
Author(s) -
Kusum D. Jashnani,
Chandrashekar V Hegde,
Shrutika P Munot
Publication year - 2013
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.116152
Subject(s) - stromal cell , sertoli cell , ovary , stroma , medicine , androgen insensitivity syndrome , alpha fetoprotein , endocrinology , pathology , biology , immunohistochemistry , androgen receptor , cancer , spermatogenesis , prostate cancer , hepatocellular carcinoma
Ovarian sex cord-stromal tumors are relatively infrequent neoplasms that account for approximately 8% of all primary ovarian tumors. They are a heterogeneous group of neoplasms composed of cells derived from gonadal sex cords (granulosa and Sertoli cells), specialized gonadal stroma (theca and Leydig cells), and fibroblasts. They may show androgenic or estrogenic manifestations. We report such a tumor associated with markedly raised serum alpha-fetoprotein (AFP) levels in a young female presenting with a mass and defeminising symptoms. Serum AFP levels returned to normal on removal of tumor.