Open AccessP-cadherin as myoepithelial cell marker for differential diagnosis of benign and malignant breast lesions
Author(s) -
Yachika Bhatia
Publication year - 2013
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.116140
Subject(s) - myoepithelial cell , immunostaining , pathology , immunohistochemistry , staining , medicine , differential diagnosis , cadherin , carcinoma , ki 67 , cell , biology , genetics
P-cadherin is cell-cell adhesion glycoprotein which can be used as a myoepithelial cell (MEC) marker in the breast lesions. MEC layer is retained in most benign lesions and loss of this outer layer is hallmark of infiltrating carcinomas in the breast.