Open AccessEpithelial mesenchymal transition in urothelial carcinoma: Twist in the tale
Author(s) -
Purnima Paliwal,
Disha Arora,
Ashwani Kumar Mishra
Publication year - 2012
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.107777
Subject(s) - vimentin , epithelial–mesenchymal transition , cytokeratin , immunohistochemistry , pathology , bladder cancer , twist transcription factor , cadherin , cancer research , mesenchymal stem cell , cancer , biology , oncology , medicine , metastasis , cell , genetics
Epithelial to mesenchymal transition (EMT) is a process involving conversion of cells from an epithelial to mesenchymal phenotype. The role of candidate genes promoting EMT and favoring a promigratory phenotype has been demonstrated in epithelial cancer. Existing scientific research has not yielded a clinically relevant biomarker with predictive capacity beyond grade and stage in bladder cancer.