Open AccessAdvanced Role of Hippo Signaling in Endometrial Fibrosis
Author(s) -
Haiyan Zhu,
T.S. Ge,
Y. B. Pan,
Songying Zhang
Publication year - 2017
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.218013
Subject(s) - hippo signaling pathway , myofibroblast , wnt signaling pathway , fibrosis , cancer research , epithelial–mesenchymal transition , transforming growth factor , signal transduction , medicine , biology , bioinformatics , microbiology and biotechnology , pathology , cancer , metastasis
Intrauterine adhesion (IUA) is a major health problem that causes infertility, menstrual irregularities, and recurrent pregnancy losses in women. Unfortunately, treatments for IUA are limited, and there are currently no effective strategies for preventing IUA recurrence. In this review, we introduced the role of Hippo signaling in the normal endometrium and IUA and described the mechanisms by which the Hippo pathway integrates with the Wnt and transforming growth factor-β (TGF-β) signaling pathways to form an intricate network governing the development of fibrosis.