Open AccessPossible Mechanism of Therapeutic Effect of 3-Methyl-1-phenyl-2-pyrazolin-5-one and Bone Marrow Stromal Cells Combination Treatment in Rat Ischemic Stroke Model
Author(s) -
Lihua Shen,
Chen Jin,
Huachao Shen,
Min Ye,
Xiaofei Liu,
Wensen Ding,
Ya-Feng Sheng,
Ding Xin-sheng
Publication year - 2016
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.183418
Subject(s) - medicine , stromal cell , neurogenesis , bone marrow , nestin , subcutaneous injection , homing (biology) , pathology , pharmacology , neuroscience , stem cell , biology , neural stem cell , ecology , genetics
The functional improvement following bone marrow stromal cells (BMSCs) transplantation after stroke is directly related to the number of engrafted cells and neurogenesis in the injured brain. Here, we tried to evaluate whether 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), a free radical scavenger, might influence BMSCs migration to ischemic brain, which could promote neurogenesis and thereby enhance treatment effects after stroke.