Open AccessInfluence of G-protein β-Polypeptide 3 C825T Polymorphism on Antihypertensive Response to Telmisartan and Amlodipine in Chinese Patients
Author(s) -
Zan-Lin Zhang,
Huilan Li,
Zhipeng Wen,
Guoping Yang,
Wei Zhang,
Xiaoping Chen
Publication year - 2016
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.172548
Subject(s) - telmisartan , amlodipine , medicine , polymorphism (computer science) , pharmacology , gastroenterology , endocrinology , genotype , chemistry , blood pressure , biochemistry , gene
G-protein β-polypeptide 3 (GNB3) is a β subunit isoform of G-protein that plays important role in signal transduction of membrane G-protein coupled receptors (GPCRs). The GNB3 splice variant C825T (rs5443) is associated with risk for essential hypertension (EH) and efficacy of therapeutic drugs targeting GPCRs. It is unknown whether the polymorphism is associated with blood pressure (BP) response to telmisartan or amlodipine, two widely prescribed antihypertensive drugs.