Open AccessDopamine Agonists Exert Nurr1-inducing Effect in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease
Author(s) -
Li Min Zhang,
Cong Sun,
Ming Shu Mo,
Luan Cen,
Lei Wei,
Fei Luo,
Yang Li,
Guo Fei Li,
Si Yun Zhang,
Yang Li,
Wei Huang,
Zhuo Lin Liu,
Wei Dong Le,
Ping Xu
Publication year - 2015
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.159349
Subject(s) - peripheral blood mononuclear cell , medicine , agonist , dopaminergic , parkinson's disease , dopamine agonist , pramipexole , endocrinology , dopamine , pharmacology , biology , in vitro , receptor , disease , biochemistry
Nurr1 plays an essential role in the development, survival, and function maintenance of midbrain dopaminergic (DA) neurons, and it is a potential target for Parkinson's disease (PD). Nurr1 mRNA can be detected in peripheral blood mononuclear cells (PBMCs), but whether there is any association of altered Nurr1 expression in PBMC with the disease and DA drug treatments remains elusive. This study aimed to measure the Nurr1 mRNA level in PBMC and evaluate the effect of Nurr1 expression by DA agents in vivo and in vitro.