Open AccessMeta-analysis for the Association of Apolipoprotein E ε2/ε3/ε4 Polymorphism with Coronary Heart Disease
Author(s) -
Yong Zhang,
Honglei Tang,
Wenjia Peng,
Bingbing Zhang,
Ming Liu
Publication year - 2015
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.156803
Subject(s) - allele , odds ratio , apolipoprotein e , medicine , confidence interval , genetic model , meta analysis , population , genetics , disease , biology , gene , environmental health
Coronary heart disease (CHD) is a multifactorial disease and is thought to have a polygenic basis. Apolipoprotein E (APOE) gene is one such candidate with its common ε2/ε3/ε4 polymorphism in CHD. In recent years, numerous case-control studies have investigated the relationship of APOE polymorphism with CHD risk. However, the results are confusing.