Open AccessCombination photodynamic therapy and bevacizumab for choroidal neovascularization associated with toxoplasmosis
Author(s) -
Pukhraj Rishi,
Anusha Venkataraman,
Ekta Rishi
Publication year - 2011
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/0301-4738.73728
Subject(s) - medicine , bevacizumab , choroidal neovascularization , photodynamic therapy , macular degeneration , ophthalmology , visual acuity , chorioretinitis , combination therapy , toxoplasmosis , surgery , chemotherapy , pathology , chemistry , organic chemistry
A 14-year-old girl presenting with visual loss in both eyes was diagnosed to have healed toxoplasma retinochoroiditis in the right eye with active choroidal neovascularization (CNV) secondary to toxoplasmosis in the left. She underwent combination photodynamic therapy (PDT) and intravitreal bevacizumab as primary treatment. PDT was performed as per the 'Treatment of Age-related Macular Degeneration by Photodynamic therapy' study protocol and was followed by intravitreal bevacizumab after 2 days. CNV regressed at 8 weeks of follow-up and remained stable at 8 months of follow-up. The initial visual acuity improved from 20/120 to 20/30. Combination therapy with PDT and intravitreal bevacizumab appears to be effective in the treatment of CNV secondary to toxoplasma retinochoroiditis.