Open AccessAnalysis of single nucleotide polymorphisms of CRYGA and CRYGB genes in control population of western Indian origin
Author(s) -
Suman Kapila,
Shipra Mehra,
Devarshi Gajjar,
Abhay R. Vasavada,
Manav Kapoor,
Shashwat Sharad,
Bhagwat V. Alapure,
Samuel A. Rajkumar
Publication year - 2009
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/0301-4738.49393
Subject(s) - single nucleotide polymorphism , genetics , genotyping , allele frequency , restriction fragment length polymorphism , gene , biology , allele , snp , exon , haplotype , coding region , intron , minor allele frequency , snp genotyping , genotype
Polymorphisms in gamma-crystallins ( CRYG ) can serve as markers for lens differentiation and eye disorders leading to cataract. Several investigators have reported the presence of sequence variations within crystallin genes, with or without apparent effects on the function of the proteins both in mice and humans. Delineation of these polymorphic sites may explain the differences observed in the susceptibility to cataract observed among various ethnic groups. An easier Restriction Fragment Length Polymorphism (RFLP)-based method has been used to detect the frequency of four single nucleotide polymorphisms (SNPs) in CRYGA / CRYGB genes in control subjects of western Indian origin.