Open AccessGentamicin-mediated ototoxicity and nephrotoxicity: A clinical trial study
Author(s) -
Parviz Saleh,
Shamsi Abbasalizadeh,
Saman Rezaeian,
Mohammad Naghavi-Behzad,
Reza Piri,
Hojjat Hossein Pourfeizi
Publication year - 2016
Publication title -
nigerian medical journal/nigerian medical journal
Language(s) - English
Resource type - Journals
eISSN - 2229-774X
pISSN - 0300-1652
DOI - 10.4103/0300-1652.193861
Subject(s) - ototoxicity , nephrotoxicity , medicine , creatinine , gentamicin , renal function , blood urea nitrogen , urology , aminoglycoside , adverse effect , antibiotics , anesthesia , toxicity , chemotherapy , cisplatin , microbiology and biotechnology , biology
Aminoglycosides and mainly gentamicin are the most important antimicrobial agents. Two different methods of administration exist: Single and multiple doses. There has always been a controversy about the less harmful administration method, to minimize adverse effects of gentamicin - deafness and renal insufficiency. In this study, it was aimed to compare two different methods of administration to figure out the least harmful treatment method.