Open AccessElevation of serum pancreatic amylase and distortion of pancreatic cyto-architecture in type 1 diabetes mellitus rats treated with Ocimum gratissimum
Author(s) -
Okon Uduak Akpan,
Rosemary B. Bassey,
Bisong Sunday Agba,
Innocent Asuquo Edegha
Publication year - 2014
Publication title -
nigerian medical journal/nigerian medical journal
Language(s) - English
Resource type - Journals
eISSN - 2229-774X
pISSN - 0300-1652
DOI - 10.4103/0300-1652.128157
Subject(s) - diabetes mellitus , medicine , streptozotocin , endocrinology , amylase , intraperitoneal injection , pancreas , gastroenterology , biology , enzyme , biochemistry
Diabetes mellitus has been shown to cause severe impairment in exocrine pancreatic function and cyto-architecture. Ocimum grattissimum has been reported to lower blood glucose levels in experimental diabetic animals. This study, therefore, aims to investigate if treatment with O. grattissimum can alleviate these pancreatic complications of diabetes mellitus. The phytoconstituents and median lethal dose of the plant extract were determined.