Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure | Zendy

Rudrashish Haldar | Zendy; Ashutosh Kaushal | Zendy; Devendra Gupta | Zendy; Shashi Srivastava | Zendy; PrabhatK Singh | Zendy; Paurush Ambesh | Zendy

Open Access

Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure

Author(s) -

Rudrashish Haldar,

Ashutosh Kaushal,

Devendra Gupta,

Shashi Srivastava,

PrabhatK Singh,

Paurush Ambesh

Publication year - 2015

Publication title -

anesthesia essays and researches

Language(s) - English

Resource type - Journals

ISSN - 0259-1162

DOI - 10.4103/0259-1162.159773

Subject(s) - ceftazidime , medicine , neurotoxicity , antibiotics , complication , anesthesia , broad spectrum , intensive care medicine , surgery , toxicity , chemistry , microbiology and biotechnology , bacteria , biology , genetics , combinatorial chemistry , pseudomonas aeruginosa

Ceftazidime is a widely used antibiotic with broad spectrum activity against Gram-positive and Gram-negative microbes and is used prophylactically in neurosurgical patients prior to surgery. Neurotoxicity is a recognized complication of ceftazidime use but is reported predominantly after repeated administration in patients with impaired renal status. We encountered a patient with an intracranial tumor who developed generalized convulsions following a single dose of ceftazidime, which was infused rapidly and attempt to provide an explanation of this uncommon occurrence.

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