Open AccessConvulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure
Author(s) -
Rudrashish Haldar,
Ashutosh Kaushal,
Devendra Gupta,
Sheela Srivastava,
Prabhat Kumar Singh,
Paurush Ambesh
Publication year - 2015
Publication title -
al-banǧ. maqālāt wa abḥāṯ fī al-taẖdīr wa-al-in’āš
Language(s) - English
Resource type - Journals
ISSN - 0259-1162
DOI - 10.4103/0259-1162.159773
Subject(s) - ceftazidime , medicine , neurotoxicity , antibiotics , complication , anesthesia , broad spectrum , intensive care medicine , surgery , toxicity , chemistry , microbiology and biotechnology , bacteria , biology , genetics , combinatorial chemistry , pseudomonas aeruginosa
Ceftazidime is a widely used antibiotic with broad spectrum activity against Gram-positive and Gram-negative microbes and is used prophylactically in neurosurgical patients prior to surgery. Neurotoxicity is a recognized complication of ceftazidime use but is reported predominantly after repeated administration in patients with impaired renal status. We encountered a patient with an intracranial tumor who developed generalized convulsions following a single dose of ceftazidime, which was infused rapidly and attempt to provide an explanation of this uncommon occurrence.