Open AccessRole of quassinoids as potential antimalarial agents: An in silico approach
Author(s) -
Shailima Rampogu
Publication year - 2015
Publication title -
ancient science of life/ancient science of life
Language(s) - English
Resource type - Journals
eISSN - 2249-9547
pISSN - 0257-7941
DOI - 10.4103/0257-7941.171676
Subject(s) - dock , docking (animal) , protein data bank (rcsb pdb) , artemisinin , protein data bank , in silico , antimalarial agent , drug discovery , chemistry , protein–ligand docking , computational biology , plasmodium falciparum , pharmacophore , malaria , pharmacology , virtual screening , stereochemistry , biology , biochemistry , protein structure , medicine , immunology , nursing , gene
Malaria is an infection caused by mosquitoes in human beings which can be dangerous if untreated. A well known plant product, quassinoids are known to have antimalarial activity. These bioactive phytochemicals belong to the triterpene family. Quassinoids are used in the present study to act against malarial dihydrofolate reductase (Pf-DHFR), a potential antimalarial target. Nevertheless, viṣama jvara (~malaria) has been treated with the bark of Cinchona since a long time.