Open AccessEvaluation of antidiabetic, antioxidant effect and safety profile of gomutra ark in Wistar albino rats
Author(s) -
Devender O Sachdev,
Devesh D Gosavi,
Kartik J Salwe
Publication year - 2012
Publication title -
ancient science of life/ancient science of life
Language(s) - English
Resource type - Journals
eISSN - 2249-9547
pISSN - 0257-7941
DOI - 10.4103/0257-7941.103180
Subject(s) - glibenclamide , malondialdehyde , alloxan , toxicity , diabetes mellitus , blood sugar , medicine , vitamin c , antioxidant , acute toxicity , urine , vitamin e , vitamin , pharmacology , traditional medicine , endocrinology , chemistry , oxidative stress , biochemistry
The effect of Gomutra ark (GoA) on experimental alloxan-induced diabetes in rats was studied. For this purpose, Wistar albino rats of either sex weighing 200-250 g were used. The biochemical parameters like blood sugar, vitamin C, and malondialdehyde release were measured. The safety profile of GoA was evaluated using acute and chronic toxicity studies. GoA significantly lowers blood glucose in diabetic rats although the observed effect was found to be less than glibenclamide. It significantly lowers the level of malondialdehyde and vitamin C in diabetic rats. No toxicity was observed even when cow urine was given 32 times of the study dose in acute toxicity and no significant changes were seen when it was used chronically, which suggests that cow urine is having a very high therapeutic index. This study supports the traditional use of GoA in diabetes and is having a high therapeutic index and is safe for chronic use. However, further studies are needed to elucidate the mechanism of action of Gomutra ark.