Analysis of gene mutations involved in chloroquine resistance inPlasmodium falciparumparasites isolated from patients in the southwest of Saudi Arabia | Zendy

Saad M. Bin Dajem | Zendy; Ahmed A. AlQahtani | Zendy

Open Access

Analysis of gene mutations involved in chloroquine resistance inPlasmodium falciparumparasites isolated from patients in the southwest of Saudi Arabia

Author(s) -

Saad M. Bin Dajem,

Ahmed A. AlQahtani

Publication year - 2010

Publication title -

annals of saudi medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.373

H-Index - 44

eISSN - 0975-4466

pISSN - 0256-4947

DOI - 10.4103/0256-4947.62826

Subject(s) - plasmodium falciparum , chloroquine , virology , malaria , drug resistance , gene , biology , plasmodium (life cycle) , mutation , genetics , parasite hosting , immunology , world wide web , computer science

Chloroquine has been the drug of choice for the treatment of malaria for many decades. We aimed to examine the molecular basis of chloroquine resistance among Plasmodium falciparum isolates from the southwestern region of Saudi Arabia by analyzing the K76T and N86Y mutations in the PfCRT and PfMDR1 genes, respectively.

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