Open AccessAnalysis of gene mutations involved in chloroquine resistance inPlasmodium falciparumparasites isolated from patients in the southwest of Saudi Arabia
Author(s) -
Saad M. Bin Dajem,
Ahmed AlQahtani
Publication year - 2010
Publication title -
annals of saudi medicine/annals of saudi medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.373
H-Index - 44
eISSN - 0975-4466
pISSN - 0256-4947
DOI - 10.4103/0256-4947.62826
Subject(s) - plasmodium falciparum , chloroquine , malaria , amplicon , drug resistance , virology , biology , gene , medicine , genetics , polymerase chain reaction , immunology
Chloroquine has been the drug of choice for the treatment of malaria for many decades. We aimed to examine the molecular basis of chloroquine resistance among Plasmodium falciparum isolates from the southwestern region of Saudi Arabia by analyzing the K76T and N86Y mutations in the PfCRT and PfMDR1 genes, respectively.