Open AccessInsulin catalyzes the curcumin-induced wound healing: An in vitro model for gingival repair
Author(s) -
Neetu Singh,
Vishal Ranjan,
Deeba Zaidi,
Hari Shyam,
Aparna Singh,
Divya Lodha,
Rishi Sharma,
Umesh Pratap Verma,
Jaya Dixit,
Anil K. Balapure
Publication year - 2012
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.99304
Subject(s) - wound healing , insulin , curcumin , apoptosis , in vitro , connective tissue , medicine , pharmacology , cancer research , chemistry , pathology , immunology , biochemistry
Human gingival fibroblasts (hGFs) play a major role in the maintenance and repair of gingival connective tissue. The mitogen insulin with IGFs etc. synergizes in facilitating wound repair. Although curcumin (CUR) and insulin regulate apoptosis, their impact as a combination on hGF in wound repair remains unknown. Our study consists of: 1) analysis of insulin-mediated mitogenesis on CUR-treated hGF cells, and 2) development of an in vitro model of wound healing.