Open AccessAllopurinol-induced DRESS syndrome
Author(s) -
Selçuk Yaylacı,
Mustafa Demır,
Tayfun Temiz,
Ali Tamer,
Mustafa İhsan Uslan
Publication year - 2012
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.96351
Subject(s) - allopurinol , medicine , eosinophilia , leukocytosis , maculopapular rash , rash , jaundice , gout , dermatology , skin biopsy , physical examination , gastroenterology , surgery , biopsy
A 70-year-old man was admitted to our clinic with complaints of fever, jaundice, dyspnea, and generalized rash after 3 months of allopurinol treatment for gout. On physical examination, he was found to have fever (38.5°C), jaundice, and generalized maculopapular rash. Leukocytosis, eosinophilia, elevation of liver enzymes, and hyperbilirubinemia were detected in his blood analysis. Skin biopsy was consistent with drug-induced hypersensitivity. He was diagnosed as Drug Rash with Eosinophilia and Systemic Symptoms (DRESS). Allopurinol treatment was stopped and steroid treatment was launched. At day 24 of admission, the patient died because of multiple organ failure.