Open AccessPharmacological investigation of memory restorative effect of riluzole in mice
Author(s) -
Puneet Rinwa,
Amteshwar Singh Jaggi,
Nirmal Singh
Publication year - 2012
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.96337
Subject(s) - tbars , riluzole , oxidative stress , morris water navigation task , pharmacology , chemistry , glutathione , acetylcholinesterase , lipid peroxidation , endocrinology , medicine , hippocampus , glutamate receptor , biochemistry , enzyme , receptor
Streptozotocin (STZ) and sodium nitrite (NaNO(2)) treatment have been positively correlated with higher incidence of memory loss and experimental dementia. The present study was designed to investigate the potential of the Riluzole, an inhibitor of glutamatergic neurotransmission and activator of TWIK-Related K(+) channels with incidences of memory deficits associated with dementia in mice.