Pharmacological investigation of memory restorative effect of riluzole in mice | Zendy

Nirmal Singh | Zendy; Puneet Rinwa | Zendy; Amteshwar Singh Jaggi | Zendy

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Pharmacological investigation of memory restorative effect of riluzole in mice

Author(s) -

Nirmal Singh,

Puneet Rinwa,

Amteshwar Singh Jaggi

Publication year - 2012

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.96337

Subject(s) - tbars , riluzole , oxidative stress , morris water navigation task , pharmacology , chemistry , glutathione , acetylcholinesterase , lipid peroxidation , endocrinology , medicine , hippocampus , glutamate receptor , biochemistry , enzyme , receptor

Streptozotocin (STZ) and sodium nitrite (NaNO(2)) treatment have been positively correlated with higher incidence of memory loss and experimental dementia. The present study was designed to investigate the potential of the Riluzole, an inhibitor of glutamatergic neurotransmission and activator of TWIK-Related K(+) channels with incidences of memory deficits associated with dementia in mice.

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