Open AccessA low dose of doxorubicin improves antioxidant defence system and modulates anaerobic metabolism during the development of lymphoma
Author(s) -
Nibha Verma,
Manjula Vinayak
Publication year - 2012
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.96299
Subject(s) - antioxidant , superoxide dismutase , pharmacology , doxorubicin , glutathione , catalase , oxidative stress , anaerobic exercise , chemistry , cardiotoxicity , biochemistry , biology , enzyme , toxicity , medicine , chemotherapy , physiology
The objective of the present study is to find low dose of doxorubicin (DOX) with cancer preventive activity and to check the implication of this low dose of DOX on antioxidant defence system during lymphoma growth in mice, as the clinical utility of anthracycline anticancer drugs, especially DOX is limited by a progressive cardiotoxicity linked to mitochondrial damage.