Open AccessEvaluation of thyroid hormone induced pharmacological preconditioning on cardiomyocyte protection against ischemic-reperfusion injury
Author(s) -
Anil Kumar,
Rajeev Taliyan,
Poonam Sharma
Publication year - 2012
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.91870
Subject(s) - mitochondrial permeability transition pore , cardioprotection , ischemia , ischemic preconditioning , lactate dehydrogenase , mptp , creatine kinase , medicine , reperfusion injury , perfusion , pharmacology , endocrinology , cardiology , chemistry , apoptosis , programmed cell death , enzyme , biochemistry , dopaminergic , dopamine
Ischemic preconditioning (IPC) has been demonstrated to make myocardium transiently more resistant to deleterious effect of prolonged ischemia. The opening of the mitochondrial permeability transition pore (mPTP) at the time of myocardial reperfusion is a critical determinant of cell death. L-thyroxine pre-treatment increases the tolerance of the heart to ischemia and produces cardioprotection similar to ischemic precondition. This study has been designed to investigate the mechanism involved in L-thyroxine-induced cardiomyocyte protection against ischemia-reperfusion (I/R) injury in rats.