The effect of chronic administration of L-arginine and L-NAME on morphine-induced antinociception in ovariectomized rats | Zendy

Mahmoud Hosseini | Zendy; Zahra Taiarani | Zendy; Reza Karami | Zendy; Azam AlaviNezhad Khalil Abad | Zendy

Open Access

The effect of chronic administration of L-arginine and L-NAME on morphine-induced antinociception in ovariectomized rats

Author(s) -

Mahmoud Hosseini,

Zahra Taiarani,

Reza Karami,

Azam AlaviNezhad Khalil Abad

Publication year - 2011

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.84969

Subject(s) - morphine , ovariectomized rat , nitric oxide , nociception , saline , nitric oxide synthase , medicine , tail flick test , analgesic , endocrinology , hot plate test , chemistry , pharmacology , hormone , receptor

The role of ovarian hormones and nitric oxide on morphine-induced antinociception and their interaction have been widely investigated. The results of previous study showed that nitric oxide synthase inhibition differently affects morphine-induced antinociception in male and female rats. The present study was carried out to evaluate the different effects of chronic administration of L-arginine (LA) and L-NAME (LN) on morphine-induced antinociception in ovariectomized (OVX) and naive female rats.

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