Open AccessThe effect of chronic administration of L-arginine and L-NAME on morphine-induced antinociception in ovariectomized rats
Author(s) -
Mahmoud Hosseini,
Zahra Taiarani,
Reza Karami,
Azam Alavi Nezhad Khalil Abad
Publication year - 2011
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.84969
Subject(s) - morphine , ovariectomized rat , nitric oxide , nociception , saline , nitric oxide synthase , medicine , tail flick test , analgesic , endocrinology , hot plate test , chemistry , pharmacology , hormone , receptor
The role of ovarian hormones and nitric oxide on morphine-induced antinociception and their interaction have been widely investigated. The results of previous study showed that nitric oxide synthase inhibition differently affects morphine-induced antinociception in male and female rats. The present study was carried out to evaluate the different effects of chronic administration of L-arginine (LA) and L-NAME (LN) on morphine-induced antinociception in ovariectomized (OVX) and naive female rats.