Open AccessComparison of the effect of vanadium and deferoxamine on acetaminophen toxicity in rats
Author(s) -
Hossein Najafzadeh,
Annahita Rezaie,
AM Masoodi,
Saeed Mehrzadi
Publication year - 2011
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.83115
Subject(s) - deferoxamine , vanadium , acetaminophen , blood urea nitrogen , creatinine , chemistry , pharmacology , sodium , toxicity , renal function , kidney , urea , saline , medicine , biochemistry , inorganic chemistry , organic chemistry
Acetaminophen (APAP) can change to toxic metabolites at high dose; if these metabolites are in high amounts, the body will be unable to neutralize them, and several tissues including liver will be damaged. In the present study, the effect of vanadium was compared with deferoxamine on hepatotoxicity and also kidney function during APAP administration in rats.