Open AccessNanotechnology in oncology: Characterization and in vitro release kinetics of cisplatin-loaded albumin nanoparticles: Implications in anticancer drug delivery
Author(s) -
Saikat Das,
L Jagan,
Rajesh Isiah,
B Rajesh,
Selvamani Backianathan,
Subhashini Jagu
Publication year - 2011
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.83111
Subject(s) - cisplatin , bioavailability , drug delivery , dynamic light scattering , nanoparticle , chemistry , pharmacology , bovine serum albumin , controlled release , kinetics , albumin , drug , in vitro , in vivo , pharmacokinetics , nephrotoxicity , biophysics , nanotechnology , materials science , toxicity , medicine , chromatography , biochemistry , chemotherapy , surgery , organic chemistry , biology , physics , quantum mechanics , microbiology and biotechnology
Nanotechnology is an empowering technology that holds promise in cancer therapeutics by increasing the ratio of tumor control probability to normal tissue complication probability. It can increase the bioavailability of the drug at the target site, reduce the frequency of administration and reach otherwise lesser-accessible sites. The present study shows the feasibility of the cisplatin-loaded albumin nanoparticle as a sustained delivery system.