Open AccessEffect of imatinib on the biochemical parameters of the reproductive function in male Swiss albino mice
Author(s) -
AM Prasad,
K Ramnarayan,
K Nalini,
KL Bairy
Publication year - 2011
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.83107
Subject(s) - imatinib , medicine , testosterone (patch) , lactate dehydrogenase , imatinib mesylate , fertility preservation , fertility , endocrinology , physiology , pharmacology , cancer research , andrology , myeloid leukemia , biology , population , enzyme , biochemistry , environmental health
Treatment of cancers with cytotoxic agents such as tyrosine kinase inhibiting drugs often, but not always, result in transient to permanent testicular dysfunction. Germ cells are important targets of many chemicals. Most of the drugs are genotoxins and induce irreversible effect on genetic makeup. These mutagenic changes are proportionally related to carcinogenesis. This is alarmingly dangerous in youth and children, since these effects last longer, affecting fertility or forming basis for carcinogenesis. There is paucity of reports on planned studies of imatinib on the testicular function. Hence, the study was planned to assess the effects of imatinib on biochemical markers of testicular functions in male Swiss albino mice.