Open AccessA comparative study of the pharmacokinetics of traditional and automated dosing/blood sampling systems using gabapentin
Author(s) -
Bijay Aryal,
Tae-Hyun Kim,
Yoon-Gyoon Kim,
Hyunggun Kim
Publication year - 2011
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.81512
Subject(s) - pharmacokinetics , blood sampling , dosing , bioavailability , volume of distribution , pharmacology , medicine , chemistry
The present study was undertaken to investigate the pharmacokinetics (PKs) of gabapentin as determined by traditional manual blood sampling and by using an automated dosing/blood sampling technique in awake and freely moving rats using combined liquid chromatography tandem mass-spectrometry (LC-MS/MS).