Open AccessEffect of quercetin on lipopolysaccharide induced-sickness behavior and oxidative stress in rats
Author(s) -
Sangeeta Pilkhwal Sah,
Naveen Tirkey,
Anurag Kuhad,
Kanwaljit Chopra
Publication year - 2011
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.77365
Subject(s) - sickness behavior , lipopolysaccharide , oxidative stress , quercetin , saline , pharmacology , medicine , malondialdehyde , endocrinology , chemistry , biochemistry , antioxidant
Gram-negative infections and control infusion of recombinant cytokines in human have been shown to induce sickness behavior characterized by fever, prolong sleep, decreased food and water intake, reduced mobility, depression, and anxiety. Therefore, the present study was undertaken to investigate the effect of bioflavonoid quercetin in lipopolysaccharide (LPS)-induced sickness behavior.