Open AccessThe effect of mitoxantrone as an anticancer drug on hepatocytes nuclei and chromatin: Selective release of histone proteins
Author(s) -
Zahra Hajihassan,
Azra Rabbani-Chadegani
Publication year - 2011
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.77362
Subject(s) - mitoxantrone , chromatin , histone , chemistry , western blot , histone h1 , microbiology and biotechnology , dna , biochemistry , biophysics , biology , genetics , chemotherapy , gene
Mitoxantrone is an anticancer drug widely used in the treatment of various cancers. In the present study the effect of mitoxantrone on chromatin proteins of intact hepatocytes nuclei was investigated and compared with soluble chromatin.