Open AccessInfluence of drug concentration on the diffusion parameters of caffeine
Author(s) -
Rym Ben Mustapha,
Christine Lafforgue,
Nadia Fenina,
JeanPaul Marty
Publication year - 2011
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.77351
Subject(s) - caffeine , permeation , penetration (warfare) , chemistry , drug , membrane , human skin , diffusion , chromatography , in vivo , ex vivo , in vitro , pharmacology , biophysics , biochemistry , medicine , physics , microbiology and biotechnology , operations research , biology , engineering , genetics , thermodynamics
In the fields of the pharmaceutical and cosmetic industries and in toxicology, the study of the skin penetration of molecules is very interesting. Various studies have considered the impact of different physicochemical drug characteristics, skin thickness, and formulations, on the transition from the surface of the skin to the underlying tissues or to the systemic circulation; however, the influence of drug concentration on the permeation flux of molecules has rarely been raised. Our study aims to discover the influence of caffeine concentration in a formulation on the percutaneous penetration from gels, as a result of different dose applications to polysulfate membrane and human skin.