Ranitidine-induced thrombocytopenia: A rare drug reaction | Zendy

AmitV Bangia | Zendy; Narendra Kamath | Zendy; Vidushi Mohan | Zendy

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Ranitidine-induced thrombocytopenia: A rare drug reaction

Author(s) -

AmitV Bangia,

Narendra Kamath,

Vidushi Mohan

Publication year - 2011

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.75676

Subject(s) - ranitidine , medicine , pancytopenia , platelet , vomiting , neutrophilia , drug , histamine h2 receptor , gastroenterology , anesthesia , pharmacology , antagonist , bone marrow , receptor

H(2) antagonist ranitidine causing thrombocytopenia is a rare drug phenomenon. Here we present a case of 55 year old female of pustular psoriasis who presented with fever and vomiting. Patient. was started on roxithromycin, iv ondensetron, paracetamol and iv ranitidine. Complete blood count revealed neutrophilia with normal blood picture. However repeat investigations showed falling WBC and platelet count. After excluding other causes of pancytopenia we concluded that ranitidine was the cause for this atypical drug reaction, more so when the blood picture improved within 72 hrs of ranitidine withdrawal.

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