Open AccessUnusual nail pigmentation following cyclophosphamide-containing chemotherapy regimen
Author(s) -
Santosh Kumar,
Rakesh Dixit,
Saurabh Karmakar,
Sayan Paul
Publication year - 2010
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.68433
Subject(s) - cyclophosphamide , medicine , dermatology , methotrexate , nail (fastener) , chemotherapy , regimen , cancer chemotherapy , surgery , materials science , metallurgy
Cyclophosphamide therapy may rarely cause pigmentation of the nails which is of different patterns. We report a patient who developed pigmentation of nails after six cycles of cyclophosphamide, methotrexate, and 5-flourouracil chemotherapy, each repeated after 28 days for breast cancer. The patient developed nail pigmentation that started proximally and spread distally and involved all the nails of both hands and feet except the second and third toenails of right foot. Using Naranjo ADR Probability Scale, the case revealed a "probable" association with cyclophosphamide.