Open AccessZidovudine-induced reversible pure red cell aplasia
Author(s) -
Anuja Balakrishnan,
Rohith Valsalan,
Shubha Sheshadri,
Vinay Pandit,
Vikas Medep,
Ravindra Agrawal
Publication year - 2010
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.66845
Subject(s) - zidovudine , pure red cell aplasia , medicine , bone marrow aplasia , indian subcontinent , anemia , hemolysis , bone marrow , human immunodeficiency virus (hiv) , aplasia , bone marrow failure , bone marrow suppression , immunology , virology , chemotherapy , viral disease , biology , history , ancient history , genetics , stem cell , haematopoiesis
Hematological abnormalities are frequent among human immunodeficiency virus (HIV)-infected patients and may be directly attributable to the virus or may be caused by opportunistic infections, neoplasms or drugs that cause bone marrow suppression or hemolysis. Pure red cell aplasia (PRCA) is an uncommon hematological disorder that causes anemia. We report a 37-year-old male with HIV infection who developed PRCA 6 weeks after commencing Zidovudine and recovered following cessation of the drug. This is the first case of Zidovudine-induced PRCA reported from the Indian subcontinent.