Expression of TNF-α and RANTES in drug-induced human gingival overgrowth | Zendy

Suresh Ranga Rao | Zendy; Tamilselvan Subramani | Zendy; Loganathan Dhanaraj | Zendy; S. Kamatchiammal | Zendy; Soundararajan Periasamy | Zendy; Georgi Abraham | Zendy

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Expression of TNF-α and RANTES in drug-induced human gingival overgrowth

Author(s) -

Suresh Ranga Rao,

Tamilselvan Subramani,

Loganathan Dhanaraj,

S. Kamatchiammal,

Soundararajan Periasamy,

Georgi Abraham

Publication year - 2010

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.66842

Subject(s) - drug , medicine , tumor necrosis factor alpha , pharmacology , immunology

Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemokine that is produced by fibroblasts, lymphoid and epithelial cells of the mucosa in response to various external stimuli. RANTES expression has been demonstrated in a variety of diseases characterized by inflammation, including asthma, transplantationassociated accelerated atherosclerosis, endometriosis and fibrosis. RANTES mRNA is quickly up-regulated by tumor necrosis factor (TNF)-α stimulation. Cyclosporine A (CsA) is widely used in organ transplant patients, often causing various side-effects including gingival overgrowth, which is fibrotic in nature. This study was carried out to assess the mRNA expression of TNF-α and RANTES in healthy individual, chronic periodontitis and CsAinduced gingival overgrowth tissues.

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