Open AccessA novel study of screening and confirmation of modafinil, adrafinil and their metabolite modafinilic acid under EI-GC-MS and ESI-LC-MS-MS ionization
Author(s) -
Sachin Dubey,
Shobha Ahi,
Indira Reddy,
Tamanpreet Kaur,
Alka Beotra,
Shubhendra Kumar Jain
Publication year - 2009
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.59928
Subject(s) - modafinil , chromatography , triple quadrupole mass spectrometer , chemistry , mass spectrometry , metabolite , gas chromatography–mass spectrometry , electrospray ionization , selected reaction monitoring , tandem mass spectrometry , pharmacology , medicine , biochemistry
Adrafinil and modafinil have received wide publicity and have become controversial in the sporting world when several athletes were discovered allegedly using these drugs as doping agents. By acknowledging the facts, the World Anti-Doping Agency (WADA) banned these drugs in sports since 2004. The present study explores the possibility of differentiating adrafinil and modafinil and their major metabolites under electron impact ionization in gas chromatograph-mass spectrometer (GC-MSD) and electrospray ionization in liquid chromatograph-mass spectrometer (LC-MS/MS) by studying the fragmentation pattern of these drugs.