Oropharyngeal aspiration of bleomycin: An alternative experimental model of pulmonary fibrosis developed in Swiss mice | Zendy

Chandraiah Godugu | Zendy; Swarna Bale | Zendy; Manoj Sunkoju | Zendy; ShivaShankar Reddy | Zendy; Veerabhadra Swamy | Zendy

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Oropharyngeal aspiration of bleomycin: An alternative experimental model of pulmonary fibrosis developed in Swiss mice

Author(s) -

Chandraiah Godugu,

Swarna Bale,

Manoj Sunkoju,

ShivaShankar Reddy,

Veerabhadra Swamy

Publication year - 2016

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.194859

Subject(s) - bleomycin , masson's trichrome stain , bronchoalveolar lavage , hydroxyproline , histopathology , pulmonary fibrosis , pathology , medicine , western blot , lung , fibrosis , malondialdehyde , oxidative stress , chemistry , biochemistry , chemotherapy , gene

Pulmonary fibrosis (PF) is a progressive and predominantly lethal form of several interstitial lung diseases with limited current therapeutics; it is, therefore, essential to develop a simple, homogeneous, and noninvasive disease model to investigate possible anti-fibrotic approaches. The present study is designed to develop oropharyngeal aspiration (OPA) model of bleomycin (BLM)-induced PF as a simple and alternative to intratracheal (IT) administration of BLM in Swiss mice strain.

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