Open AccessOropharyngeal aspiration of bleomycin: An alternative experimental model of pulmonary fibrosis developed in Swiss mice
Author(s) -
Swarna Bale,
Manoj Sunkoju,
Shiva Shankar Reddy,
Veerabhadra Swamy,
Chandraiah Godugu
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.194859
Subject(s) - bleomycin , masson's trichrome stain , bronchoalveolar lavage , hydroxyproline , histopathology , pulmonary fibrosis , pathology , medicine , western blot , lung , fibrosis , malondialdehyde , oxidative stress , chemistry , biochemistry , chemotherapy , gene
Pulmonary fibrosis (PF) is a progressive and predominantly lethal form of several interstitial lung diseases with limited current therapeutics; it is, therefore, essential to develop a simple, homogeneous, and noninvasive disease model to investigate possible anti-fibrotic approaches. The present study is designed to develop oropharyngeal aspiration (OPA) model of bleomycin (BLM)-induced PF as a simple and alternative to intratracheal (IT) administration of BLM in Swiss mice strain.