Open AccessMetabolism-mediated interaction potential of standardized extract of Tinospora cordifolia through rat and human liver microsomes
Author(s) -
Shiv Bahadur,
Pulok K. Mukherjee,
Sk Milan Ahmmed,
Amit Kar,
Ranjit K. Harwansh,
Subrata Pandit
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.190758
Subject(s) - tinospora cordifolia , cyp1a2 , cyp3a4 , microsome , pharmacology , ic50 , chemistry , cyp2c9 , cyp2d6 , cytochrome p450 , isozyme , biochemistry , traditional medicine , enzyme , biology , in vitro , medicine
Tinospora cordifolia is used for treatment of several diseases in Indian system of medicine. In the present study, the inhibition potential of T. cordifolia extracts and its constituent tinosporaside to cause herb-drug interactions through rat and human liver cytochrome enzymes was evaluated.