Open AccessTherapeutic insight into molsidomine, a nitric oxide donor in streptozotocin-induced diabetic nephropathy in rats
Author(s) -
Nathani Minaz,
Rema Razdan
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.190744
Subject(s) - molsidomine , diabetic nephropathy , oxidative stress , streptozotocin , diabetes mellitus , endocrinology , malondialdehyde , medicine , nitric oxide , kidney , lipid peroxidation , renal function , nephropathy , creatinine , pharmacology , chemistry
Diabetes-induced oxidative stress and hypertension play a major role in the development of nephropathy. Hence, the present study was undertaken to evaluate the protective effects of molsidomine, a nitric oxide donor in streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats.