Open AccessScorpion (Androctonus bicolor) venom exhibits cytotoxicity and induces cell cycle arrest and apoptosis in breast and colorectal cancer cell lines
Author(s) -
Abdulrahman Alasmari,
Anvarbatcha Riyasdeen,
Rajamohamed Abbasmanthiri,
Mohammed Arshaduddin,
Fahad Al-Harthi
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.190742
Subject(s) - propidium iodide , apoptosis , cytotoxicity , cell cycle checkpoint , cell cycle , scorpion venoms , cancer cell , venom , biology , cytotoxic t cell , scorpion , programmed cell death , cell growth , microbiology and biotechnology , cancer , cancer research , pharmacology , biochemistry , in vitro , genetics
The defective apoptosis is believed to play a major role in the survival and proliferation of neoplastic cells. Hence, the induction of apoptosis in cancer cells is one of the targets for cancer treatment. Researchers are considering scorpion venom as a potent natural source for cancer treatment because it contains many bioactive compounds. The main objective of the current study is to evaluate the anticancer property of Androctonus bicolor scorpion venom on cancer cells.