Scorpion (Androctonus bicolor) venom exhibits cytotoxicity and induces cell cycle arrest and apoptosis in breast and colorectal cancer cell lines | Zendy

AbdulrahmanK Al-Asmari | Zendy; Anvarbatcha Riyasdeen | Zendy; Rajamohamed Abbasmanthiri | Zendy; Mohammed Arshaduddin | Zendy; FahadAli Al-Harthi | Zendy

Open Access

Scorpion (Androctonus bicolor) venom exhibits cytotoxicity and induces cell cycle arrest and apoptosis in breast and colorectal cancer cell lines

Author(s) -

AbdulrahmanK Al-Asmari,

Anvarbatcha Riyasdeen,

Rajamohamed Abbasmanthiri,

Mohammed Arshaduddin,

FahadAli Al-Harthi

Publication year - 2016

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.190742

Subject(s) - propidium iodide , apoptosis , cytotoxicity , cell cycle checkpoint , cell cycle , scorpion venoms , cancer cell , venom , biology , cytotoxic t cell , scorpion , programmed cell death , cell growth , microbiology and biotechnology , cancer , cancer research , pharmacology , biochemistry , in vitro , genetics

The defective apoptosis is believed to play a major role in the survival and proliferation of neoplastic cells. Hence, the induction of apoptosis in cancer cells is one of the targets for cancer treatment. Researchers are considering scorpion venom as a potent natural source for cancer treatment because it contains many bioactive compounds. The main objective of the current study is to evaluate the anticancer property of Androctonus bicolor scorpion venom on cancer cells.

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