Role of antioxidant property of carvedilol in mild to moderate hypertensive patients: A prospective open-label study | Zendy

Hamid Yaghooti | Zendy; Saleh Ayashi | Zendy; Ahmadreza Assareh | Zendy; Mohammad Taha Jalali | Zendy; Samaneh Olapour | Zendy

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Role of antioxidant property of carvedilol in mild to moderate hypertensive patients: A prospective open-label study

Author(s) -

Hamid Yaghooti,

Saleh Ayashi,

Ahmadreza Assareh,

Mohammad Taha Jalali,

Samaneh Olapour

Publication year - 2016

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.186206

Subject(s) - carvedilol , medicine , antioxidant , prospective cohort study , pharmacology , chemistry , biochemistry , heart failure

Carvedilol is a nonselective third generation β-blocker that does not display the negative effects of traditional β-blockers. Regarding the antioxidant, anti-inflammatory and distinct metabolic properties of carvedilol which are similar to that of high-density lipoprotein (HDL) and paraoxonase 1 (PON1), the present study intends to investigate the effects of carvedilol treatment on malondialdehyde (MDA) and soluble lectin-like ox-low-density lipoprotein (LDL) receptor (sLOX-1) as markers of oxidative stress in association to lipid profiles, apolipoproteins (apo), and PON1 activity in hypertensive patients.

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