Open AccessRole of antioxidant property of carvedilol in mild to moderate hypertensive patients: A prospective open-label study
Author(s) -
Saleh Ayashi,
Ahmadreza Assareh,
Mohammad Taha Jalali,
Samaneh Olapour,
Hamid Yaghooti
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.186206
Subject(s) - carvedilol , medicine , antioxidant , prospective cohort study , pharmacology , chemistry , biochemistry , heart failure
Carvedilol is a nonselective third generation β-blocker that does not display the negative effects of traditional β-blockers. Regarding the antioxidant, anti-inflammatory and distinct metabolic properties of carvedilol which are similar to that of high-density lipoprotein (HDL) and paraoxonase 1 (PON1), the present study intends to investigate the effects of carvedilol treatment on malondialdehyde (MDA) and soluble lectin-like ox-low-density lipoprotein (LDL) receptor (sLOX-1) as markers of oxidative stress in association to lipid profiles, apolipoproteins (apo), and PON1 activity in hypertensive patients.