Open AccessEvaluation of CYP2C19, P2Y12, and ABCB1 polymorphisms and phenotypic response to clopidogrel in healthy Indian adults
Author(s) -
Kannan Sridharan,
Rachna Kataria,
Drishti Tolani,
Shital R. Bendkhale,
Nithya J Gogtay,
Urmila M Thatte
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.186191
Subject(s) - cyp2c19 , clopidogrel , p2y12 , pharmacodynamics , genotype , bioavailability , medicine , platelet , pharmacology , polymorphism (computer science) , population , pharmacokinetics , aspirin , biology , genetics , gene , environmental health
CYP2C19 and P2Y12 polymorphisms have been claimed to alter the pharmacodynamic response to clopidogrel. ABCB1 polymorphism has been associated with the efflux of clopidogrel resulting in decreased bioavailability. Due to paucity of data from Indian population, the present study was undertaken to evaluate the association of genetic polymorphisms of CYP2C19, P2Y12, and ABCB1 with inhibition of platelet aggregation (IPA) by clopidogrel.