Open AccessMethanolic extract of Anthocephalus cadamba induces apoptosis in Ehrlich ascites carcinoma cells in experimental mice
Author(s) -
Narayan Dolai,
Aminul Islam,
Pallab Kanti Haldar
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.186190
Subject(s) - apoptosis , propidium iodide , biology , microbiology and biotechnology , flow cytometry , annexin , ehrlich ascites carcinoma , comet assay , acridine orange , staining , ethidium bromide , blot , dna damage , dna , programmed cell death , in vitro , biochemistry , gene , genetics
Anthocephalus cadamba (Roxb.) Miq. (Family: Rubiaceae), a folk medicine commonly known as "Kadam" in Bengali, has been used for the treatment of tumor. The methanolic extract of A. cadamba (MEAC) showing antitumor activity on Ehrlich ascites carcinoma (EAC) cells treated mice was already reported. This study was designed to study the apoptosis-inducing property of MEAC and its mechanism in EAC cells in mice.