Open AccessAmphotericin B liposome-induced acrocyanosis and elevated serum creatinine
Author(s) -
Xiangcai Zhang,
Jie Jin,
Chuang Cai,
Ru-ru Zheng,
Yu Wang,
Yingying Xu
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.182889
Subject(s) - amphotericin b , liposome , creatinine , medicine , adverse effect , adverse drug reaction , pharmacology , gastroenterology , dermatology , drug , chemistry , antifungal , biochemistry
A 77-year-old male patient developed acrocyanosis and pain after treatment with amphotericin B liposome 150 mg daily intravenously for disseminated histoplasmosis, and subsequently developed elevated serum creatinine. Amphotericin B liposome was discontinued, and anisodamine was used intravenously to treat acrocyanosis and pain induced by amphotericin B liposome for 9 days and patient was cured. Naranjo adverse drug reaction probability scale score was 5, the World Health Organization-Uppsala Monitoring Centre criteria: Probable, indicating a probable adverse reaction to amphotericin B liposome.