Amphotericin B liposome-induced acrocyanosis and elevated serum creatinine | Zendy

Yingying Xu | Zendy; Xiangcai Zhang | Zendy; Jie Jin | Zendy; Chuang Cai | Zendy; Ren Zheng | Zendy; Yu Wang | Zendy

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Amphotericin B liposome-induced acrocyanosis and elevated serum creatinine

Author(s) -

Yingying Xu,

Xiangcai Zhang,

Jie Jin,

Chuang Cai,

Ren Zheng,

Yu Wang

Publication year - 2016

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.182889

Subject(s) - amphotericin b , liposome , creatinine , medicine , adverse effect , adverse drug reaction , pharmacology , gastroenterology , dermatology , drug , chemistry , antifungal , biochemistry

A 77-year-old male patient developed acrocyanosis and pain after treatment with amphotericin B liposome 150 mg daily intravenously for disseminated histoplasmosis, and subsequently developed elevated serum creatinine. Amphotericin B liposome was discontinued, and anisodamine was used intravenously to treat acrocyanosis and pain induced by amphotericin B liposome for 9 days and patient was cured. Naranjo adverse drug reaction probability scale score was 5, the World Health Organization-Uppsala Monitoring Centre criteria: Probable, indicating a probable adverse reaction to amphotericin B liposome.

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